Journal of Medicinal and Chemical Sciences

Synthesis, Characterization, and Preliminary Evaluation of Ferulic Acid Derivatives Containing Heterocyclic Moiety

Samir A. Malik; Karima F. Ali; Ashour H. Dawood

Volume 6, Issue 6 , June 2023, , Pages 1444-1456

https://doi.org/10.26655/JMCHEMSCI.2023.6.24

Abstract

This study aimed to synthesize new ferulic acid derivatives through preparing new compounds containing a heterocyclic group that are expected to be biologically effective for diagnosis ... Read More

Congenital Anomalies of Urinary Tract in Kosovo Population Diagnosed by Renal Scintigraphy

Ramë Miftari; Hana Maloku; Valdete Topciu; Aferdita Bajqinca; Ylli Kaciu; Milazim Shabani; Mimoza Ukimeraj; Betim Maloku

Volume 6, Issue 6 , June 2023, , Pages 1457-1468

https://doi.org/10.26655/JMCHEMSCI.2023.6.25

Abstract

Congenital kidney and urinary tract abnormalities are considered among common congenital anomalies in people, resulting in loss of renal function and progression to the kidney disease ... Read More

Relationship between Adjuvant Thiamine, Ascorbic Acid, and Combinations of These Drugs with Reducing the Incidence, Increasing MMP-9/TIMP-1 Ratio, and Decreasing Score Sofa in Mechanically Ventilated Patients with Severe Sepsis or Septic Shock

Agus Prima; Rr Sinta Irina; Bastian Lubis

Volume 6, Issue 5 , May 2023, , Pages 1055-1064

https://doi.org/10.26655/JMCHEMSCI.2023.5.11

Abstract

A high number of sepsis patients demand all health institutions to provide adequate treatment and management. Several therapeutic agents are developed as adjuvants for handling sepsis ... Read More

Prevalence and Molecular Detection of Bacteria Isolated from Sexually Transmitted Disease in Al-Anbar Province

Leqaa M. Aziz; Mohammed A. Hamad; Eman Majed Al-Hadethy; Mustafa. A. Saud; Firas R. R Jameel

Volume 6, Issue 5 , May 2023, , Pages 1077-1086

https://doi.org/10.26655/JMCHEMSCI.2023.5.13

Abstract

This study is the first in the Al-Anbar governorate with this design aim to the detection of Sexually transmitted diseases (STDs) by using RT-PCR. A total of (70) samples were obtained ... Read More

Intravenous Lidocaine in Management of Acute Pain in Traumatic Limb: Evidence-Based Systematic Review

Roohie Farzaneh; Mohammad Sadegh Sanie Jahromi; Samaneh Abiri; Behrang Rezvani Kakhki; Shahram Shefa; Reza Akhavan; Somayeh Ahmadnezhad; Bita Abbasi; Hossein Akhavan; Fatemeh Maleki; Mahdi Foroughian

Volume 6, Issue 5 , May 2023, , Pages 1145-1154

https://doi.org/10.26655/JMCHEMSCI.2023.5.20

Abstract

Lidocaine is one of the medications that is proposed as an alternative in acute pain management. Lidocaine is routinely used in topical and dental anesthesia and is known for its analgesic ... Read More

Cilostazol Protects Against Sepsis-Induced Kidney Impairment in a Mice Model

Abdulla K K Raheem; Ahmed R. Abu-Raghif; Qassim A Zigam

Volume 6, Issue 5 , May 2023, , Pages 1193-1203

https://doi.org/10.26655/JMCHEMSCI.2023.5.25

Abstract

Sepsis is a type of systemic inflammatory disease caused by polymicrobial infection. To investigate the potential reno-protective benefits of cilostazol during sepsis-induced renal ... Read More

Antibacterial Activity of Bacteriocin - Isolated from Lactobacillus Spp. Against Some Pathogenic Bacteria

Susan Saab Manfi Al-Rawi; Omar Dheyauldeen Salahdin; Farah Tareq Al-Alaq; Lubna Abdulazeem; Mazin H. Kzar; Essam Shawky Khattab; Ahmed Samir Naje

Volume 6, Issue 4 , April 2023, , Pages 702-709

https://doi.org/10.26655/JMCHEMSCI.2023.4.1

Abstract

Objective: A member of the lactic acid bacteria (LAB) group, lactobacilli are well-known for their probiotic properties. They also possess several unique properties, including the ability ... Read More

Biological Test of Porous Geopolymer as a Bone Substitute

Haifaa Abdul Ameer Radhi; Maha Abdulaziz Ahmad

Volume 6, Issue 4 , April 2023, , Pages 710-719

https://doi.org/10.26655/JMCHEMSCI.2023.4.2

Abstract

Bone substitute materials in the current use sustain several drawbacks such as donor site morbidity, induce immunity, availability, and economic production. New synthetic bone substitutes ... Read More

Association of BCL11A Gene Polymorphism in Human Cells of Thalassemia Patient by Evaluation of Amplification Refractory Mutation System (ARMS)

Zahraa Qasim Mousa; Maytham A. Dragh

Volume 6, Issue 4 , April 2023, , Pages 834-845

https://doi.org/10.26655/JMCHEMSCI.2023.4.15

Abstract

Thalassemia is an autosomal recessive disorder. It occurs due to mutations that lead to a decrease or absence of β-globin chains. In human erythroid cells, it was found that BCL11A ... Read More

The Study of BCL11A Gene in Patients with Beta-Thalassemia Major and Intermedia by Random Amplephed Polymorphism DNA in Iraq

Zahraa Qasim Mousa; Maytham A. Dragh

Volume 6, Issue 4 , April 2023, , Pages 846-856

https://doi.org/10.26655/JMCHEMSCI.2023.4.16

Abstract

Thalassemia Autosomal recessive disorders occur due to mutations that lead to a decrease or absence of b-globin chains because mutations occur in the BCL11A gene being a potential therapeutic ... Read More

Phytochemical Analysis, GCMS Identification, and Estimation of Antioxidant Activity of Iraqi Vitex negundo L.

Tahany A. Tawfeeq; Amani A. Tawfeeq; Rasha Eldalawy; Shamis Khaleel Ibraheem

Volume 6, Issue 4 , April 2023, , Pages 876-883

https://doi.org/10.26655/JMCHEMSCI.2023.4.19

Abstract

Vitex negundo Linn, known as chaste tree, belongs to Verbenaceae family. It is a woody medicinal tree; an aromatic and flowering-ornamental plant has different ethnobotanical and pharmacological ... Read More

Using GC-MS Technology to Identify the Compounds Resulting from Mixing of Alcoholic Extracts of Some Medicinal Plants

Maryam Mansoor Mathkoor; Eussur Noory Alkhfaji; Noor Abd-Ulamer Oda

Volume 6, Issue 3 , March 2023, , Pages 486-499

https://doi.org/10.26655/JMCHEMSCI.2023.3.5

Abstract

Phytochemicals are considered as one of the most important pharmaceutical compounds used in pharmacy at all, due to their high therapeutic efficacy and few side effects compared with ... Read More

Evaluation of Anti-atherosclerotic Effects of Melatonin Interference with Inflammatory and Oxidative Stress Pathway in Male Rabbits

Hajar Nazar Hashem; Fadhil A. Rizij

Volume 6, Issue 3 , March 2023, , Pages 559-568

https://doi.org/10.26655/JMCHEMSCI.2023.3.13

Abstract

Atherosclerosis is the primary cause of death worldwide. It is now commonly acknowledged that it is a persistent inflammatory process. Minor inflammation, increased oxidative stress, ... Read More Atherosclerosis is the primary cause of death worldwide. It is now commonly acknowledged that it is a persistent inflammatory process. Minor inflammation, increased oxidative stress, and lipid peroxidation all play the essential roles in the atherosclerosis progression. Melatonin (N-acetyl-5-methoxytryptamine) is a neuroendocrine hormone discovered in the bovine pineal gland. The antioxidant action of melatonin is manifested to its direct effects via M1,2 receptors. It not only increases antioxidant enzymes, but also suppresses mesenchymal cell apoptosis. Melatonin is anti-inflammatory and anti-oxidant. In contrast to well-known Instead of following an enzymatic pathway of reduction after oxidation, as do endogenous antioxidants such carotene and vitamins E and C, melatonin binds permanently to free radicals, which the kidneys eliminate. In comparison to the induced untreated group, melatonin has a significant impact on lipid parameters (P>0.001). Melatonin significantly reduced the elevation in ICAM and a mild effect on the aorta thickness compared with induced untreated groups (P<0.05). The drug restores aortic GSH and SOD level (P<0.001). The aim of this research is to evaluate whether melatonin can protect rabbits against atherosclerosis and their role in inflammatory and oxidative pathway. Twenty-four domestic male rabbits from the surrounding area were divided into three groups: Group One, normal Control group (n = 8). Group Two (n = 8): Rabbits were fed a 1% cholesterol diet (induced untreated group). Group Three (n = 8): 1% cholesterol diet + oral melatonin 10 mg/kg once per day before breakfast. Animals fed with an atherogenic diet had lower levels of GSH, SOD, and higher levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density cholesterol, very low-density cholesterol, a therogenic index, iCAM, and intimal thickness of the aorta, as compared with controls (P<0.001). In comparison with the induced untreated group, melatonin has a significant impact on lipid parameters (P>0.001). Melatonin significantly reduced the ICAM elevation and a mild effect on aorta thickness compared with induced untreated groups (p<0.05). The drug restore aortic GSH and SOD level (P<0.001). The findings of the current study suggest that melatonin reduce the evolution of atherosclerosis in by meddling with inflammatory and oxidative processes and affecting lipid parameters, it was possible to treat hypercholesterolemic rabbits.

The Effects of Levosimendan Against Sepsis-Induced Cardiotoxicity in Mice Model

Qassim A Zigam; Adeeb A. Al-Zubaidy; Zahraa Sami; Weaam J Abbas

Volume 6, Issue 3 , March 2023, , Pages 634-644

https://doi.org/10.26655/JMCHEMSCI.2023.3.20

Abstract

Sepsis is an upregulated systemic inflammatory reaction that has been identified as a global health concern. It can lead to multiple organ toxicity, including cardiac, hepatic, and ... Read More Sepsis is an upregulated systemic inflammatory reaction that has been identified as a global health concern. It can lead to multiple organ toxicity, including cardiac, hepatic, and renal dysfunction. Sepsis can result in cardiomyocyte impairment, hypertrophy, and heart failure by increasing oxidative stress and the expression of pro-inflammatory cytokines. Furthermore, elevated cardiac troponin-I (cTn-I) during sepsis impairs heart contractile performance by decreasing myofilament response to calcium. The current study aimed to examine the possible effects of levosimendan against sepsis-induced cardiotoxicity. Forty male mice 8-12 weeks old and weighing 25-30 grams. After two weeks of acclimation, the mice were separated into four groups (n = 10): (1) Healthy group (n = 10). (2) CLP group: CLP operation was performed on mice. (3) DMSO group (4) Levosimendan group: 10 mg/kg intraperitoneally (IP) in 2 divided doses for 5 consecutive days. All groups underwent the CLP procedure on the fourth day, were sacrificed on the fifth day, and then samples were taken. The Levosimendan group exhibited a significant (p < 0.05) decrease in myocardial troponin-I concentration compared to the CLP group. In addition, the inflammatory cytokines (TNF-α, IL-6, and IL-1β) serum levels in the levosimendan group were significantly (p < 0.05) lower than in the CLP group. In addition, the levosimendan group demonstrated a significant (p0.05) increase in myocardial SOD activity and a decrease in MDA level compared to the CLP mice. Histopathologically, the levosimendan group demonstrated a statistically significant (p0.05) reduction in cardiac tissue damage. Levosimendan attenuates sepsis-induced cardiotoxicity via multiple protective effects, including anti-inflammatory and antioxidant effects, according to the findings of the present study. In addition, the direct cardiac protective effect via the decreased cardiac troponin-I level and the attenuation of histopathological alterations during sepsis-induced cardiotoxicity.

The Importance of Early Diagnosis of Systemic Scleroderma

A.Sh. Baimashev; E.R. Agisheva; A.E. Simonova; O.A. Sorokina; D.A. Prokofiev

Volume 6, Issue 2 , February 2023, , Pages 177-185

https://doi.org/10.26655/JMCHEMSCI.2023.2.1

Abstract

Systemic scleroderma (SSc) is a progressive and severely debilitating autoimmune disease characterized by inflammation, vasculopathy, and extensive fibrosis. SSc is highly heterogeneous ... Read More

Role of Kaempferol Combined with Pioglitazone in the Alleviation of Inflammation and Modulation of Necroptosis and Apoptosis Pathways in NASH-induced Mice

Asmaa R. Abdel-Hamed; Amir O. Hamouda; Dina M. Abo-elmatty; Naglaa F. Khedr; Maivel H. Ghattas

Volume 6, Issue 2 , February 2023, , Pages 250-268

https://doi.org/10.26655/JMCHEMSCI.2023.2.8

Abstract

Background: Nonalcoholic steatohepatitis (NASH) is one of the most serious health problems in the world. Apoptosis and necroptosis signaling pathways are highly implicated in NASH. ... Read More

Wounding-To-Door Time Metrics Outcome of Traumatic Simple Wounds in Emergency Department

Roohie Farzaneh; Mohadese Arvan; Nazgol Khodaie; Sara Rahsepar; Arman Hakemi; Fatemeh Maleki; Mahdi Foroughian; Somayyeh Ahmadnezhad

Volume 6, Issue 2 , February 2023, , Pages 304-312

https://doi.org/10.26655/JMCHEMSCI.2023.2.11

Abstract

Objective: To examine the relationship between wounding-to-door time and wound healing duration in patients with simple traumatic wounds admitted to Shahid Rajaei Emergency Department ... Read More

Cancer and Complications of Peptic Ulcer in Type 2 Diabetes Mellitus patients at Wasit province, Iraq

Muna Mohammed Yaseen; Sami Awad Alkubaisy; Walid Theib Mohammad; Abduladheem Turki Jalil; Saja Hussain Dilfy

Volume 6, Issue 2 , February 2023, , Pages 335-345

https://doi.org/10.26655/JMCHEMSCI.2023.2.14

Abstract

Diabetes is one of the health challenges for decades, which is concurrent with many pathological disorders. Hence so the aim of the current study aims is to clarify the relationship ... Read More

Evaluation of Urinary Tract Infection and Measurement of Interleukin 18 in Iraqi Patients with Rheumatoid Arthritis

Esraa Mohammed Jasim; Sanaa Khudhur Jameel; Nabaa Ihsan Awadh

Volume 6, Issue 2 , February 2023, , Pages 440-448

https://doi.org/10.26655/JMCHEMSCI.2023.2.24

Abstract

Although the etiology of RA is complicated, infection with various microorganisms can activate several immune system pathways, potentially leading to an autoimmune response. Urinary ... Read More

Uterine Adenomyosis Relationship with Gravidity, Parity, and Abortion in Women with a History of Infertility: A Case-Control Retrospective Study

Athar Rasekhjahromi; Tanaz Torabi; Farideh Mogharab; Mahshid Alborzi; Navid Kalani

Volume 6, Issue 1 , January 2023, , Pages 1-8

https://doi.org/10.26655/JMCHEMSCI.2023.1.1

Abstract

Introduction: Adenomyosis is reported to be increasingly diagnosed in young women and affects 20 to 35% of women of reproductive age. This study aimed to evaluate the relationship between ... Read More

Conjugation of Cortistatin Peptide with Gold Nanoparticles Synthesized to Investigate Anti-Inflammatory Effects in Allergic Asthma

Didar Mehrabi Nasab; Alireza Taheri; Seyyed Shamsadin Athari

Volume 6, Issue 1 , January 2023, , Pages 20-28

https://doi.org/10.26655/JMCHEMSCI.2023.1.3

Abstract

In this study, conjugation between Cortistatin peptide and gold nanoparticles was performed for effective drug delivery of peptide to lung tissue to investigate its anti-inflammatory ... Read More

Demographic Characteristics, Clinical Features, Laboratory, and Radiological Findings in Children Admitted to COVID19 Center in Amara City, Misan Province, Iraq

Eman Khammas AlSaadi; Mohammed A. Darweesh; Hussain Fadel Al Jawadi; Mohammed Abdul-Mounther Othman

Volume 6, Issue 1 , January 2023, , Pages 34-43

https://doi.org/10.26655/JMCHEMSCI.2023.1.5

Abstract

Background:Most pediatric patients with covid 19 had mild to moderate infection and some had severe challenging infection. Generally, they had variable signs and symptoms, laboratory, ... Read More Background:Most pediatric patients with covid 19 had mild to moderate infection and some had severe challenging infection. Generally, they had variable signs and symptoms, laboratory, and radiological findings correlated with the patient age, the involved system, disease severity and probably any underlying disease.Aim:To identify the most common clinical features, the frequency of positive radiological findings, and laboratory results of the infected children hospitalized in Misan COVID-19 Center.Materials and method:A retrospective descriptive with some analytic study applied on 100 pediatric patients in the age range of (0-16) years, diagnosed with COVID-19 or were highly suspected cases, depending on clinical findings, laboratory tests, COVID-19 RT-PCR and/or chest (X-ray + CT), whom were admitted to the Pediatric Covid -19 Center in Amara City, Iraq during the time period of (February-June, 2021). Their medical records were reviewed for demographic information, (gender, age, and residence), medical history, clinical examination, laboratory and imaging studies, (X-ray + CT), O saturation, the duration of illness before admission of any underlying chronic diseases as well as the most common presenting signs and symptoms.Results:Children infected slightly more in the age range of (5-10 years), boys slightly more infected than girls as (54%) and (46%), respectively. The urban residents suffered more than the rural ones, 4% of all cases had low O2 saturation. Fever and malaise were the most common presenting symptoms as (93%) and (68%), respectively. The illness duration before hospitalization commonly was (<5days), (RT-PCR) was negative in 45% of patients, 54% had anemia with or without leukopenia and lymphopenia, CTs were positive in (62%) and CXR was positive in (53%), while the underlying chronic diseases were found in (23%) of the cases.Conclusion: Children of ages between (5-<10 years) were slightly more infected than others, fever, malaise, and cough were the most common manifestations, the urban predominance is high, and half of patients had anemia about one third and had lymphopenia. Likewise, one forth had thrombocytopenia, negative Covid-19 (RT-PCR), and/or CXR. The CT results did not exclude infection. Thus, we need further local studies to support our results.

Vitamin D in Mild to Moderate COVID-19: A Retrospective Cross-Sectional Study

Reza Sahraeai; Farhang Hooshmand; Mojtaba Ghaedi; Shahram Shafa; Fatemeh Eftekharian; Samira Farrokhi

Volume 6, Issue 1 , January 2023, , Pages 55-61

https://doi.org/10.26655/JMCHEMSCI.2023.1.7

Abstract

Background: Vitamin D linkage with COVID-19 is investigated in many studies, but there is still no single summation. Thus, this study aimed to evaluate the relationship between Vitamin ... Read More

Moral Distress, COVID-19, and Healthcare Workers, a Systematic Review and Meta-Synthesis: Solutions by JUMS Clinical Decision-making Scheme

Marzieh Haghbeen; Hossein Hakimelahi; Mansour Tafvizi; Naser Hatami; Navid Kalani; Lotfollah Dezhkam

Volume 6, Issue 1 , January 2023, , Pages 71-78

https://doi.org/10.26655/JMCHEMSCI.2023.1.9

Abstract

Background: Although studies are conducted on moral distress during the COVID-19 period, those being conducted by using various methods of moral distress assessment, the majority of ... Read More

Hypothyroidism Risk and Its Correlation to Metabolic Parameters

Mahmood Hasen Shuhata Alubiady

Volume 6, Issue 1 , January 2023, , Pages 86-92

https://doi.org/10.26655/JMCHEMSCI.2023.1.11

Abstract

Hypothyroidism has become more prevalent in recent years. This rise might be attributed to changes in the metabolic features of the individuals. The goal of this study was to see if ... Read More

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

Main Subjects = Pharmaceutical sciences

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